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Reproductive Genetics

Reproductive Genetics

It is estimated that genetics contribute up to 10% of infertility issues or recurrent pregnancy losses in couples. The risk of finding chromosomal abnormalities grows as the age of the woman increases. Most embryos with an incorrect number of chromosomes fail to implant or miscarry during the first trimester of pregnancy. Genetic testing protocols have the potential to help many of those couples in their quest to have a family. Our comprehensive list of genetic testing services can greatly increase your chances of getting pregnant.

Treatment profile

PGT-A (Preimplantation Genetic Testing - Aneuploidy)

PGT-A is genetic testing performed on embryos to identify numerical chromosomal abnormalities or aneuploidy. This test is performed on embryos prior to transfer into the uterus. By analysing all embryos generated in an IVF treatment cycle, those free of chromosomal aneuploidy can be identified for selective transfer. As a result, the pregnancy rates per transfer are increased and the miscarriage rates decreased.

PGT-M (Preimplantation Genetic Testing – Monogenic)

PGT-M involves testing of embryos for specific monogenic disorders like thalassemia, haemophilia and certain types of muscular dystrophy. It helps couples who have a family history or those who have had a child affected with these disorders to have an unaffected child. All embryos formed as a part of an Assisted Reproductive Technology (ART) are tested for this specific monogenic disorder. Only unaffected or career embryos are transferred to have a disease free child. This can also be combined with PGT-A to further improve success rates.

PGT-SR (Preimplantation Genetic Testing - Structural Rearrangement)

PGT-SR tests people with chromosome rearrangements (structures that hold our genetic material is not of normal size or arrangement). These people are at risk of producing embryos with unbalanced chromosomal structure. Such embryos are not viable and can result in multiple miscarriages. PGT-SR tests embryos for such specific rearrangements and can help in selection of normal embryos for transfer.

ERA (Endometrial Receptivity Array)

ERA is a personalised genetic test to diagnose the state of endometrial receptivity in the window of implantation. ERA determines the exact time period during which an embryo needs to be transferred into the woman’s uterus to achieve a successful pregnancy.

Who is this for?

  • For patients who have had implantation failure with embryos of good morphological quality (at least 3 failed embryo transfers for women younger than 37 years or 2 failed transfer in women older than 37 years)
  • For patients with a normal uterus and with normal endometrial thickness (≤6mm), in which no problems are apparent